Book Appointment

Polynucleotides: A New Era in Skin Regeneration

London Dermatology | 2 June 2025

Polynucleotides are a groundbreaking development in skin rejuvenation, offering a highly effective way to achieve smoother, healthier, and more youthful skin. Often referred to on social media as the “salmon sperm treatment”, this innovative therapy is gaining popularity for its impressive ability to restore and refresh tired or ageing skin.

What are polynucleotides?

Polynucleotides are naturally derived molecules made up of nucleotides, the building blocks of DNA. These powerful substances support cellular regeneration and tissue repair, which makes them highly valuable in advanced skincare. Sourced from purified salmon DNA, they are completely safe and biologically compatible with human skin.

Key benefits

Polynucleotide injections offer a wide range of benefits:

  • Improved skin hydration and moisture retention

  • Stimulation of collagen and elastin production

  • Enhanced skin texture and elasticity

  • Repair of UV-related damage

  • Support for skin healing and tissue regeneration

They are especially useful for those who want to improve the overall health and resilience of their skin, rather than simply adding volume or tightening.

How do they compare to other treatments?

While both Profhilo and polynucleotides are used to rejuvenate skin, they work in different ways. Profhilo uses hyaluronic acid to hydrate and plump the skin, improving structure and firmness. Polynucleotides, on the other hand, promote deep cellular repair by encouraging natural healing processes, increasing blood flow, and stimulating new tissue growth.

Where can polynucleotides be used?

Polynucleotides are especially popular for treatment in the under-eye area, where skin is thin and the first signs of ageing often appear. Unlike tear-trough fillers, which add volume, polynucleotides strengthen and thicken the skin, reducing the appearance of dark circles and hollowness.

They can also be used in many other areas where skin laxity is present, including:

  • Backs of the arms

  • Stomach

  • Décolletage

  • Knees

This makes them a versatile choice for anyone looking to tighten, smooth, and refresh the skin in multiple areas.

A natural boost for your skin

Polynucleotides offer a gentle but powerful solution for skin ageing and damage. With their ability to support healing, boost hydration, and rebuild the skin’s structure from within, they are fast becoming a favourite for clients seeking long-term, natural-looking results.

Book a consultation at Devonshire Dermatology to discover whether polynucleotides are the right treatment for your skin goals.